⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18016480 | 0.71 | FUCA1 (0.32) | — | |
| SCHEMBL22454044 | 0.69 | — | — | |
| SCHEMBL18722723 | 0.69 | — | — | |
| SCHEMBL3238830 | 0.69 | — | — | |
| SCHEMBL4460537 | 0.69 | — | — | |
| SCHEMBL4460539 | 0.69 | — | — | |
| SCHEMBL18937674 | 0.67 | — | — | |
| SCHEMBL3698323 | 0.64 | MEN1 (0.37) | — | |
| SCHEMBL17702826 | 0.64 | MEN1 (0.37) | — | |
| SCHEMBL11006613 | 0.64 | MEN1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230055475-A1 | METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION | SEAGEN INC (US) | 2023-02-23 | — | — | US | disclosed |
| US-11319526-B2 | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation | SEAGEN INC. (US) | 2022-05-03 | — | — | US | disclosed |
| US-11033561-B2 | Methods of inhibition of protein fucosylation in vivo using fucose analogs | SEAGEN INC. (US) | 2021-06-15 | — | — | US | disclosed |
| US-20200061091-A1 | METHODS OF INHIBITION OF PROTEIN FUCOSYLATION IN VIVO USING FUCOSE ANALOGS | SEATTLE GENETICS, INC. (US) | 2020-02-27 | — | — | US | disclosed |
| US-10443035-B2 | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation | SEATTLE GENETICS, INC. (US) | 2019-10-15 | — | — | US | disclosed |
| US-20190276796-A1 | METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION | SEAGEN INC. | 2019-09-12 | — | — | US | disclosed |
| US-10350228-B2 | Treatment of sickle cell disease and inflammatory conditions | SEATTLE GENETICS, INC. (US) | 2019-07-16 | — | — | US | disclosed |
| US-10342811-B2 | Methods of inhibition of protein fucosylation in vivo using fucose analogs | SEATTLE GENETICS, INC. (US) | 2019-07-09 | — | — | US | disclosed |
| US-20180155677-A1 | METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION | SEAGEN INC. | 2018-06-07 | — | — | US | disclosed |
| US-9816069-B2 | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation | SEATTLE GENETICS, INC. (US) | 2017-11-14 | — | — | US | disclosed |
| US-20150238509-A1 | TREATMENT OF SICKLE CELL DISEASE AND INFLAMMATORY CONDITIONS | SEAGEN INC. | 2015-08-27 | — | — | US | disclosed |
| EP-2887947-A1 | TREATMENT OF SICKLE CELL DISEASE AND INFLAMMATORY CONDITIONS | Seattle Genetics, Inc. (US) | 2015-07-01 | — | — | EP | disclosed |
| US-8993326-B2 | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation | SEATTLE GENETICS, INC. (US) | 2015-03-31 | — | — | US | disclosed |
| WO-2014031875-A1 | TREATMENT OF SICKLE CELL DISEASE AND INFLAMMATORY CONDITIONS | SEATTLE GENETICS, INC. (US) | 2014-02-27 | — | — | WO | disclosed |
| US-20140031536-A1 | METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION | SEATTLE GENETICS, INC. (US) | 2014-01-30 | — | — | US | disclosed |
| US-8574907-B2 | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation | SEATTLE GENETICS, INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-20130129784-A1 | METHODS OF INHIBITION OF PROTEIN FUCOSYLATION IN VIVO USING FUCOSE ANALOGS | SEATTLE GENETICS, INC. (US) | 2013-05-23 | — | — | US | disclosed |
| US-20120183997-A1 | METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION | SEATTLE GENETICS, INC. (US) | 2012-07-19 | — | — | US | disclosed |
| US-8163551-B2 | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation | SEATTLE GENETICS, INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-20090317869-A1 | METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION | SEATTLE GENETICS, INC. (US) | 2009-12-24 | — | — | US | disclosed |