Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 20/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2099741 | 1.00 | GCK (0.65) | GCK | |
| SCHEMBL2098783 | 0.91 | GCK (0.70) | GCK | |
| SCHEMBL2098786 | 0.91 | GCK (0.70) | GCK | |
| SCHEMBL2099430 | 0.90 | GCK (0.70) | GCK | |
| SCHEMBL2099426 | 0.90 | GCK (0.70) | GCK | |
| SCHEMBL2098024 | 0.89 | GCK (0.67) | GCK | |
| SCHEMBL2098027 | 0.89 | GCK (0.67) | GCK | |
| SCHEMBL2100517 | 0.88 | GCK (0.67) | GCK | |
| SCHEMBL2100520 | 0.88 | GCK (0.67) | GCK | |
| SCHEMBL2098228 | 0.86 | GCK (0.72) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120252814-A1 | Glucokinase Activators | TAKEDA CALIFORNIA, INC. (US) | 2012-10-04 | — | — | US | claimed |
| US-20090105255-A1 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. | 2009-04-23 | — | — | US | claimed |
| US-8530499-B2 | Glucokinase activators | TAKEDA SAN DIEGO, INC. (US) | 2013-09-10 | — | — | US | disclosed |
| US-20120252814-A1 | Glucokinase Activators | TAKEDA CALIFORNIA, INC. (US) | 2012-10-04 | — | — | US | disclosed |
| US-8163779-B2 | Glucokinase activators | TAKEDA SAN DIEGO, INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-20090105255-A1 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120252814-A1 | Glucokinase Activators | GCK, GCKR, GALK1 | GCK 1/4885 |
| US-20090105255-A1 | GLUCOKINASE ACTIVATORS | GCK, GCKR, GALK1 | GCK 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.