Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 10/20 | 0.56 |
| ▸ | NOS1 | P29475 | 5/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PAH | P00439 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28511850 | 0.90 | HPRT1 (0.54) | HPRT1NOS1USP2CASP7HSD17B10 | |
| SCHEMBL4713155 | 0.83 | HPRT1 (0.76) | HPRT1 | |
| Phosphoric Acid SCHEMBL15054256 | 0.83 | HPRT1 (0.74) | HPRT1 | |
| SCHEMBL23223517 | 0.82 | HPRT1 (0.51) | HPRT1NOS1USP2CASP7HSD17B10 | |
| SCHEMBL23223496 | 0.82 | HPRT1 (0.47) | HPRT1 | |
| SCHEMBL7132437 | 0.79 | HPRT1 (0.60) | HPRT1NOS1USP2CASP7HSD17B10 | |
| SCHEMBL2775722 | 0.78 | HPRT1 (0.55) | HPRT1NOS1USP2CASP7HSD17B10 | |
| SCHEMBL28513633 | 0.77 | HPRT1 (0.72) | HPRT1ALDH1A1BLMKMT2A | |
| SCHEMBL7745028 | 0.75 | HPRT1 (0.64) | HPRT1NOS1USP2CASP7HSD17B10 | |
| SCHEMBL7142937 | 0.75 | HPRT1 (0.64) | HPRT1NOS1USP2CASP7HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3578563-B1 | GUANINE ANALOGS AS TELOMERASE SUBSTRATES AND TELOMERE LENGTH AFFECTORS | GERON CORP (US) | 2021-04-14 | — | — | EP | disclosed |
| EP-2794624-B1 | GUANINE ANALOGS AS TELOMERASE SUBSTRATES AND TELOMERE LENGTH AFFECTORS | GERON CORP (US) | 2019-05-15 | — | — | EP | disclosed |