SCHEMBL20998617

SCHEMBL20998617

C=CC(=O)NC1CCCN(c2ccc(C(N)=O)c(Nc3ccc(C(=O)N4CCOCC4)cc3)n2)C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BTK Q06187 20/20 1.00
KCNH2 Q12809 4/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16671754 1.00 BTK (1.00) BTKKCNH2
SCHEMBL16671028 0.95 BTK (1.00) BTKKCNH2
SCHEMBL16676809 0.95 BTK (1.00) BTKKCNH2
SCHEMBL18044931 0.95 BTK (1.00) BTKKCNH2
SCHEMBL893054 0.90 BTK (0.82) BTK
SCHEMBL895046 0.90 BTK (0.82) BTK
SCHEMBL893055 0.90 BTK (0.82) BTK
SCHEMBL18044990 0.89 BTK (0.85) BTKKCNH2
SCHEMBL18044991 0.89 BTK (0.85) BTKKCNH2
SCHEMBL893913 0.88 BTK (0.78) BTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3060550-B1 HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF MERCK PATENT GMBH (DE) 2019-05-15 EP disclosed