SCHEMBL21005488

SCHEMBL21005488

N#Cc1cc(F)cc(Oc2ccc(SC(F)F)c(CO)c2Br)c1

nearest known ligand 0.68

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EPAS1 Q99814 13/20 0.68
VEGFA P15692 10/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21005167 0.88 EPAS1 (0.68) EPAS1VEGFA
SCHEMBL21005037 0.86 EPAS1 (0.67) EPAS1VEGFA
SCHEMBL21005387 0.85 EPAS1 (0.63) EPAS1VEGFA
SCHEMBL21005036 0.83 EPAS1 (0.66) EPAS1VEGFA
SCHEMBL18036761 0.81 EPAS1 (1.00) EPAS1VEGFA
SCHEMBL21741379 0.77 EPAS1 (0.68) EPAS1VEGFA
SCHEMBL21005469 0.76 EPAS1 (0.63) EPAS1VEGFA
SCHEMBL21005040 0.76 EPAS1 (0.61) EPAS1VEGFA
SCHEMBL18689864 0.75 EPAS1 (0.64) EPAS1VEGFA
SCHEMBL21005472 0.74 EPAS1 (0.68) EPAS1VEGFA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3417851-B1 ARYL ETHERS AND USES THEREOF PELOTON THERAPEUTICS INC (US) 2020-07-22 EP disclosed
EP-3417852-B1 ARYL ETHERS AND USES THEREOF PELOTON THERAPEUTICS INC (US) 2020-02-19 EP disclosed
EP-3043784-B9 ARYL ETHERS AND USES THEREOF PELOTON THERAPEUTICS INC (US) 2019-11-20 EP disclosed
EP-3043784-B1 ARYL ETHERS AND USES THEREOF PELOTON THERAPEUTICS INC (US) 2019-05-15 EP disclosed