Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14926281 | 0.78 | PDE2A (0.49) | GAAHRH3SMN1; SMN2ATML3MBTL1 | |
| SCHEMBL14930399 | 0.74 | SMN1; SMN2 (0.51) | GAASMN1; SMN2ATML3MBTL1ALDH1A1 | |
| SCHEMBL17473523 | 0.74 | SMN1; SMN2 (0.48) | GAASMN1; SMN2ATML3MBTL1HSP90AA1 | |
| SCHEMBL14912963 | 0.73 | SMN1; SMN2 (0.47) | GAASMN1; SMN2ATML3MBTL1NPC1 | |
| SCHEMBL17473498 | 0.70 | SMN1; SMN2 (0.41) | GAASMN1; SMN2ATML3MBTL1ALDH1A1 | |
| SCHEMBL2214941 | 0.68 | HPGD (0.50) | GAASMN1; SMN2ATML3MBTL1ALDH1A1 | |
| SCHEMBL2210279 | 0.66 | HTT (0.43) | HRH3SMN1; SMN2L3MBTL1ALDH1A1KMT2A | |
| SCHEMBL17076827 | 0.66 | HPGD (0.48) | GAASMN1; SMN2ATML3MBTL1ALDH1A1 | |
| SCHEMBL3648328 | 0.66 | KMT2A (0.43) | SMN1; SMN2ALDH1A1KMT2APOLBMEN1 | |
| SCHEMBL27228782 | 0.66 | KDM4E (0.62) | SMN1; SMN2ATML3MBTL1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3002284-B1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS AS INHIBITORS OF BTK ACTIVITY | HOFFMANN LA ROCHE (CH) | 2019-05-22 | — | — | EP | disclosed |