Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 12/20 | 0.67 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21019148 | 0.89 | AAK1 (0.61) | AAK1DYRK1A | |
| SCHEMBL21018876 | 0.87 | AAK1 (0.66) | AAK1DYRK1AMAOA | |
| SCHEMBL21019439 | 0.81 | AAK1 (0.66) | AAK1DYRK1A | |
| SCHEMBL20164885 | 0.80 | AAK1 (1.00) | AAK1DYRK1A | |
| SCHEMBL20164887 | 0.80 | AAK1 (1.00) | AAK1DYRK1A | |
| SCHEMBL21019088 | 0.79 | AAK1 (0.63) | AAK1DYRK1AMAOA | |
| SCHEMBL27939882 | 0.77 | DYRK1A (0.73) | AAK1DYRK1AMAOA | |
| SCHEMBL21019158 | 0.76 | AAK1 (0.50) | AAK1DYRK1AMAOA | |
| SCHEMBL21019093 | 0.75 | AAK1 (0.66) | AAK1DYRK1A | |
| SCHEMBL19946130 | 0.75 | AAK1 (0.55) | AAK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3292124-B1 | 6H-ISOCHROMENO[3,4-C]PYRIDINES AND BENZO[C][1,7]NAPHTHYRIDIN-6-(5H)-ONES AS ADAPTOR ASSOCIATED KINASE 1 (AAK1) INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2019-05-22 | — | — | EP | disclosed |