SCHEMBL21021983

SCHEMBL21021983

Nc1cc(NC(=O)c2cc(NC(=O)C3[C@H](c4ccc(Cl)c(Cl)c4)C3(Cl)Cl)ccc2Cl)c(F)cc1F

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 7/20 0.41
MEN1 O00255 6/20 0.41
LMNA P02545 4/20 0.41
ALDH1A1 P00352 2/20 0.37
RECQL P46063 1/20 0.37
FADS1 O60427 1/20 0.37
MAPT P10636 3/20 0.37
MAPK1 P28482 1/20 0.37
HDAC1 Q13547 2/20 0.36
GRM4 Q14833 1/20 0.35
RORC P51449 1/20 0.35
KDM4E B2RXH2 1/20 0.35
SLC2A1 P11166 1/20 0.34
HTT P42858 3/20 0.34
CSF1R P07333 1/20 0.34
PYGL P06737 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19442259 1.00 KMT2A (0.41) KMT2AMEN1LMNAALDH1A1RECQL
SCHEMBL18146885 1.00 KMT2A (0.41) KMT2AMEN1LMNAALDH1A1RECQL
SCHEMBL29425605 1.00 KMT2A (0.41) KMT2AMEN1LMNAALDH1A1RECQL
SCHEMBL21021197 0.97 KMT2A (0.42) KMT2AMEN1LMNAALDH1A1RECQL
SCHEMBL18146716 0.97 KMT2A (0.42) KMT2AMEN1LMNAALDH1A1RECQL
SCHEMBL19442272 0.97 KMT2A (0.42) KMT2AMEN1LMNAALDH1A1RECQL
SCHEMBL24281490 0.95 KMT2A (0.43) KMT2AMEN1LMNAALDH1A1RECQL
SCHEMBL18160607 0.95 MEN1 (0.43) KMT2AMEN1LMNAALDH1A1RECQL
SCHEMBL20051323 0.95 KMT2A (0.43) KMT2AMEN1LMNAALDH1A1RECQL
SCHEMBL21021186 0.93 KMT2A (0.41) KMT2AMEN1LMNAALDH1A1RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3964495-A1 MOLECULES HAVING PESTICIDAL UTILITY, AND COMPOSITIONS, AND PROCESSES, RELATED THERETO Dow AgroSciences LLC (US) 2022-03-09 EP disclosed
EP-3578543-A1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO Dow AgroSciences LLC (US) 2019-12-11 EP disclosed
EP-3283459-B1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO DOW AGROSCIENCES LLC (US) 2019-05-22 EP disclosed