SCHEMBL21022437

SCHEMBL21022437

O=Cc1cc(NC(=O)C2C(c3ccc(F)c(Cl)c3)C2(Cl)Cl)ccc1Cl

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 10/20 0.51
MEN1 O00255 9/20 0.51
LMNA P02545 3/20 0.51
ALDH1A1 P00352 3/20 0.46
RECQL P46063 1/20 0.46
MAPT P10636 2/20 0.45
MAPK1 P28482 1/20 0.45
SLC2A1 P11166 1/20 0.43
NR1I2 O75469 1/20 0.39
AHR P35869 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
TSHR P16473 1/20 0.39
GAA P10253 1/20 0.38
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
HTT P42858 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
MALT1 Q9UDY8 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21021853 0.91 MEN1 (0.46) KMT2AMEN1LMNAALDH1A1RECQL
SCHEMBL21022502 0.89 KMT2A (0.47) KMT2AMEN1LMNAALDH1A1RECQL
SCHEMBL23465696 0.89 KMT2A (0.47) KMT2AMEN1LMNAALDH1A1RECQL
SCHEMBL21021926 0.86 MEN1 (0.46) KMT2AMEN1LMNAALDH1A1RECQL
SCHEMBL21022282 0.86 MEN1 (0.49) KMT2AMEN1LMNAALDH1A1RECQL
SCHEMBL21022044 0.85 MEN1 (0.52) KMT2AMEN1LMNAALDH1A1RECQL
SCHEMBL18163593 0.84 KMT2A (0.51) KMT2AMEN1LMNAALDH1A1RECQL
SCHEMBL18147008 0.84 MEN1 (0.54) KMT2AMEN1LMNAALDH1A1RECQL
SCHEMBL18146335 0.84 MEN1 (0.54) KMT2AMEN1LMNAALDH1A1RECQL
SCHEMBL19651309 0.84 MEN1 (0.54) KMT2AMEN1LMNAALDH1A1RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3283459-B1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO DOW AGROSCIENCES LLC (US) 2019-05-22 EP disclosed