SCHEMBL21022697

SCHEMBL21022697

Cc1cccc(C#N)c1-c1c(C)cccc1C#N

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.65
HTR1A P08908 1/20 0.42
DRD2 P14416 1/20 0.42
HTR7 P34969 1/20 0.42
USP8 P40818 1/20 0.41
ALOX15 P16050 1/20 0.40
CASP1 P29466 1/20 0.40
CASP7 P55210 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
CYP1A2 P05177 2/20 0.39
CYP2C19 P33261 1/20 0.39
AR P10275 3/20 0.39
KDM4E B2RXH2 2/20 0.38
ALDH1A1 P00352 2/20 0.38
USP2 O75604 1/20 0.38
CLK1 P49759 1/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CYP2A6 P11509 1/20 0.38
MAP2K1 Q02750 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21022696 0.98 TSHR (0.62) TSHRHTR1ADRD2HTR7USP8
SCHEMBL28637531 0.88 TSHR (0.52) TSHRHTR1ADRD2HTR7USP8
SCHEMBL4450143 0.85 TSHR (0.59) TSHRALOX15CYP1A2CYP2C19KDM4E
SCHEMBL2186547 0.85 TSHR (0.59) TSHRHTR1ADRD2HTR7USP8
SCHEMBL28641928 0.84 AR (0.49) TSHRCASP7ARKDM4EALDH1A1
SCHEMBL1132593 0.82 TSHR (0.61) TSHRHTR1ADRD2HTR7USP8
SCHEMBL15536685 0.82 TSHR (0.61) TSHRHTR1ADRD2HTR7USP8
SCHEMBL2732615 0.82 TSHR (0.50) TSHRHTR1ADRD2HTR7USP8
SCHEMBL1379432 0.81 TSHR (0.60) TSHRUSP8ALOX15CASP1CASP7
SCHEMBL15536129 0.81 TSHR (0.54) TSHRHTR1ADRD2HTR7USP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190157570-A1 COMPOSITION, THIN FILM INCLUDING THE COMPOSITION, AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE THIN FILM SAMSUNG ELECTRONICS CO LTD (KR) 2019-05-23 US disclosed