Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 6/20 | 0.63 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13911918 | 0.91 | NOTUM (0.76) | NOTUMTP53TRIM24ALDH1A1CYP3A4 | |
| SCHEMBL24011079 | 0.87 | NOTUM (0.84) | NOTUMTP53TRIM24ALDH1A1LMNA | |
| SCHEMBL18216843 | 0.83 | KDM4E (0.53) | NOTUMTP53TRIM24ALDH1A1LMNA | |
| SCHEMBL25690949 | 0.83 | CYP3A4 (0.47) | NOTUMTP53ALDH1A1LMNATSHR | |
| SCHEMBL156256 | 0.80 | NOTUM (0.82) | NOTUMTP53ALDH1A1LMNATSHR | |
| SCHEMBL6721657 | 0.80 | NOTUM (0.64) | NOTUMTP53ALDH1A1LMNATSHR | |
| SCHEMBL11607914 | 0.80 | NOTUM (0.64) | NOTUMTP53ALDH1A1LMNATSHR | |
| SCHEMBL4520413 | 0.79 | NOTUM (0.62) | NOTUMTP53ALDH1A1LMNATSHR | |
| SCHEMBL20894496 | 0.79 | NOTUM (0.62) | NOTUMTP53ALDH1A1LMNATSHR | |
| SCHEMBL3102790 | 0.79 | NOTUM (0.62) | NOTUMTP53ALDH1A1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11168070-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2021-11-09 | — | — | US | disclosed |
| US-20200399244-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2020-12-24 | — | — | US | disclosed |
| US-10696655-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2020-06-30 | — | — | US | disclosed |
| US-20190152949-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2019-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200399244-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | EP300, HDAC1, HDAC3 | NOTUM 3793/4885TP53 2338/4885TRIM24 2652/4885 |
| US-20190152949-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | EP300, HDAC1, HDAC11 | NOTUM 3820/4885TP53 2245/4885TRIM24 2581/4885 |
| US-11168070-B2 | Therapeutic compounds and uses thereof | EP300, HDAC1, HDAC11 | NOTUM 3820/4885TP53 2245/4885TRIM24 2581/4885 |
| US-10696655-B2 | Therapeutic compounds and uses thereof | EP300, HDAC1, HDAC11 | NOTUM 3820/4885TP53 2245/4885TRIM24 2581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.