Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | APLNR | P35414 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 3/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6344084 | 0.89 | GAA (0.43) | GAABTKKMT2AMEN1MAPK1 | |
| SCHEMBL15600327 | 0.87 | GAA (0.44) | GAABTKKMT2AMEN1MAPK1 | |
| SCHEMBL31168732 | 0.86 | GAA (0.43) | GAABTKKMT2AMEN1MAPK1 | |
| SCHEMBL2074992 | 0.83 | GAA (0.51) | GAABTKKMT2AMEN1MAPK1 | |
| SCHEMBL22145377 | 0.81 | GAA (0.42) | GAABTKKMT2AMEN1MAPK1 | |
| SCHEMBL573789 | 0.80 | GAA (0.61) | GAABTKKMT2AMEN1MAPK1 | |
| SCHEMBL4492849 | 0.80 | BTK (0.58) | GAABTKKMT2AMEN1MAPK1 | |
| SCHEMBL54785 | 0.79 | GAA (0.40) | GAABTKKMT2AMEN1MAPK1 | |
| SCHEMBL31021350 | 0.79 | KMT2A (0.45) | GAABTKKMT2AMEN1MAPK1 | |
| SCHEMBL5287930 | 0.78 | GAA (0.64) | GAABTKKMT2AMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3119765-B1 | HETEROARYL SYK INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2019-07-17 | — | — | EP | disclosed |
| EP-3119772-B1 | HETEROARYL SIK INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2019-05-22 | — | — | EP | disclosed |