Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 7/20 | 0.77 |
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.77 |
| ▸ | IRAK1 | P51617 | 5/20 | 0.77 |
| ▸ | ALK | Q9UM73 | 8/20 | 0.72 |
| ▸ | MET | P08581 | 2/20 | 0.72 |
| ▸ | EGFR | P00533 | 5/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29937816 | 1.00 | MAP3K7 (0.77) | MAP3K7IRAK4IRAK1ALKMET | |
| SCHEMBL21026016 | 1.00 | MAP3K7 (0.77) | MAP3K7IRAK4IRAK1ALKMET | |
| SCHEMBL15200278 | 0.94 | ALK (0.81) | MAP3K7IRAK4IRAK1ALKMET | |
| SCHEMBL20985379 | 0.90 | IRAK4 (0.62) | MAP3K7IRAK4IRAK1ALKMET | |
| SCHEMBL20985380 | 0.90 | IRAK4 (0.62) | MAP3K7IRAK4IRAK1ALKMET | |
| SCHEMBL21026265 | 0.90 | IRAK4 (0.62) | MAP3K7IRAK4IRAK1ALKMET | |
| SCHEMBL21025772 | 0.90 | EGFR (0.71) | MAP3K7IRAK4IRAK1ALKMET | |
| SCHEMBL21026264 | 0.90 | EGFR (0.71) | MAP3K7IRAK4IRAK1ALKMET | |
| SCHEMBL20985265 | 0.90 | MAP3K7 (0.83) | MAP3K7IRAK4IRAK1ALKMET | |
| SCHEMBL20985268 | 0.90 | MAP3K7 (0.83) | MAP3K7IRAK4IRAK1ALKMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12036209-B2 | Compounds and methods for the targeted degradation of Interleukin-1 receptor-associated kinase 4 polypeptides | ARVINAS OPERATIONS, INC. (US) | 2024-07-16 | — | — | US | disclosed |
| US-12036209-B2 | Compounds and methods for the targeted degradation of Interleukin-1 receptor-associated kinase 4 polypeptides | ARVINAS OPERATIONS, INC. (US) | 2024-07-16 | — | — | US | disclosed |
| US-11065231-B2 | Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides | ARVINAS OPERATIONS, INC. (US) | 2021-07-20 | — | — | US | disclosed |
| US-20190151295-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 POLYPEPTIDES | ARVINAS OPERATIONS, INC. | 2019-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190151295-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 POLYPEPTIDES | IRAK1, IRAK4, IRAK2 | MAP3K7 536/4885IRAK4 2/4885IRAK1 1/4885 |
| US-12036209-B2 | Compounds and methods for the targeted degradation of Interleukin-1 receptor-associated kinase 4 polypeptides | IRAK1, IRAK4, IRAK2 | MAP3K7 533/4885IRAK4 2/4885IRAK1 1/4885 |
| US-11065231-B2 | Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides | IRAK1, IRAK4, IRAK2 | MAP3K7 536/4885IRAK4 2/4885IRAK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.