Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 19/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19741405 | 0.92 | CHRM4 (0.67) | CHRM4CYP3A4CYP2C9 | |
| SCHEMBL30187957 | 0.92 | CHRM4 (0.67) | CHRM4CYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL19741448 | 0.91 | CHRM4 (0.66) | CHRM4CYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL30193487 | 0.91 | CHRM4 (0.66) | CHRM4CYP3A4CYP2C9 | |
| SCHEMBL30187319 | 0.86 | CHRM4 (0.54) | CHRM4 | |
| SCHEMBL19741087 | 0.86 | CHRM4 (0.54) | CHRM4 | |
| SCHEMBL30187292 | 0.86 | CHRM4 (0.56) | CHRM4 | |
| SCHEMBL19741261 | 0.86 | CHRM4 (0.56) | CHRM4 | |
| SCHEMBL21048225 | 0.86 | CHRM4 (0.54) | CHRM4 | |
| SCHEMBL19741056 | 0.84 | CHRM4 (0.75) | CHRM4CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230014109-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2023-01-19 | — | — | US | disclosed |
| US-11142532-B2 | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 | VANDERBILT UNIVERSITY (US) | 2021-10-12 | — | — | US | disclosed |
| US-20190161498-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2019-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230014109-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | CHRM4, CHRM5, CHRM2 | CHRM4 1/4885CYP3A4 981/4885CYP2C9 2683/4885 |
| US-11142532-B2 | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 | CHRM4, CHRM5, CHRM2 | CHRM4 1/4885CYP3A4 981/4885CYP2C9 2683/4885 |
| US-20190161498-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | CHRM4, CHRM5, CHRM2 | CHRM4 1/4885CYP3A4 981/4885CYP2C9 2683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.