Sugi Predict

Sugi Predict / Compounds / SCHEMBL21028698

SCHEMBL21028698

SCHEMBL21028698

CC(C)n1c(Cn2nc(-c3cc(O)cc(F)c3)c3c(N)nc(-c4cc(Cl)c5c(=O)n(C6CC6)c(Cn6nc(I)c7c(N)ncnc76)cc5c4)nc32)cc2cccc(Cl)c2c1=O

nearest known ligand 0.50

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ PIK3CD O00329 8/20 0.50
▸ PIK3CG P48736 10/20 0.46
▸ PIK3C2B O00750 8/20 0.43
▸ PIK3CB P42338 3/20 0.43
▸ PIK3CA P42336 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9884207 0.86 PIK3CD (0.62) PIK3CDPIK3CGPIK3C2BPIK3CBPIK3CA
SCHEMBL9884204 0.86 PIK3CD (0.65) PIK3CDPIK3CGPIK3C2BPIK3CBPIK3CA
SCHEMBL9884168 0.80 PIK3CD (0.75) PIK3CDPIK3CGPIK3C2BPIK3CBPIK3CA
SCHEMBL9884200 0.79 PIK3CD (0.67) PIK3CDPIK3CGPIK3C2BPIK3CBPIK3CA
SCHEMBL9884205 0.79 PIK3CD (0.45) PIK3CDPIK3CGPIK3CBPIK3CA
SCHEMBL9884129 0.78 PIK3CD (0.77) PIK3CDPIK3CGPIK3C2BPIK3CBPIK3CA
SCHEMBL9884206 0.78 PIK3CD (0.56) PIK3CDPIK3CGPIK3C2BPIK3CBPIK3CA
SCHEMBL9884197 0.78 PIK3CD (0.46) PIK3CDPIK3CGPIK3CBPIK3CA
SCHEMBL9884203 0.78 PIK3CD (0.67) PIK3CDPIK3CGPIK3C2BPIK3CBPIK3CA
SCHEMBL9884182 0.77 PIK3CD (0.75) PIK3CDPIK3CGPIK3C2BPIK3CBPIK3CA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2240452-B1 1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE DERIVATIVES AS PI3 KINASE MODULATORS, THEIR COMPOSITIONS AND USES INTELLIKINE LLC (US) 2019-05-29 — — EP disclosed