Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | UBE2N | P61088 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27262693 | 0.89 | SMN1; SMN2 (0.50) | SMN1; SMN2MAPK1MEN1KMT2ANPSR1 | |
| SCHEMBL377171 | 0.86 | APEX1 (0.48) | SMN1; SMN2MAPK1MEN1KMT2ANPSR1 | |
| SCHEMBL29798808 | 0.86 | APEX1 (0.48) | SMN1; SMN2MAPK1MEN1KMT2ANPSR1 | |
| SCHEMBL1953482 | 0.85 | MAPK1 (0.62) | SMN1; SMN2MAPK1MEN1KMT2ANPSR1 | |
| SCHEMBL5947663 | 0.81 | APEX1 (0.47) | SMN1; SMN2MAPK1MEN1KMT2ANPSR1 | |
| SCHEMBL28378699 | 0.79 | MAPK1 (0.59) | SMN1; SMN2MAPK1MEN1KMT2ANPSR1 | |
| SCHEMBL2976214 | 0.79 | HTT (0.39) | SMN1; SMN2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL784634 | 0.79 | MEN1 (0.43) | SMN1; SMN2MAPK1MEN1KMT2ANPSR1 | |
| SCHEMBL20219215 | 0.79 | MEN1 (0.41) | SMN1; SMN2MAPK1MEN1KMT2ANPSR1 | |
| SCHEMBL12353579 | 0.79 | NPSR1 (0.46) | SMN1; SMN2MAPK1MEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951158-B1 | PROCESS FOR THE PREPARATION OF IVACAFTOR AND SOLVATES THEREOF | GLENMARK PHARMACEUTICALS LTD (IN) | 2019-05-29 | — | — | EP | disclosed |