Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.68 |
| ▸ | EGFR | P00533 | 8/20 | 0.68 |
| ▸ | ITK | Q08881 | 5/20 | 0.66 |
| ▸ | LCK | P06239 | 5/20 | 0.66 |
| ▸ | TEC | P42680 | 4/20 | 0.66 |
| ▸ | BMX | P51813 | 4/20 | 0.66 |
| ▸ | LYN | P07948 | 4/20 | 0.66 |
| ▸ | JAK3 | P52333 | 4/20 | 0.66 |
| ▸ | TXK | P42681 | 2/20 | 0.66 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.66 |
| ▸ | ABL1 | P00519 | 2/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.66 |
| ▸ | FYN | P06241 | 2/20 | 0.66 |
| ▸ | YES1 | P07947 | 2/20 | 0.66 |
| ▸ | HCK | P08631 | 2/20 | 0.66 |
| ▸ | FGR | P09769 | 2/20 | 0.66 |
| ▸ | SRC | P12931 | 2/20 | 0.66 |
| ▸ | FER | P16591 | 2/20 | 0.66 |
| ▸ | CSK | P41240 | 2/20 | 0.66 |
| ▸ | BLK | P51451 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20995773 | 1.00 | BTK (0.68) | BTKEGFRITKLCKTEC | |
| SCHEMBL20995710 | 1.00 | BTK (0.68) | BTKEGFRITKLCKTEC | |
| SCHEMBL17065747 | 0.94 | BTK (0.71) | BTKEGFRITKLCKTEC | |
| SCHEMBL20995663 | 0.93 | BTK (0.59) | BTKEGFRITKLCKTEC | |
| SCHEMBL20995810 | 0.91 | BTK (0.62) | BTKEGFRITKLCKTEC | |
| SCHEMBL19176244 | 0.89 | BTK (0.71) | BTKEGFRITKLCKTEC | |
| SCHEMBL18335282 | 0.89 | BTK (0.75) | BTKEGFRITKLCKTEC | |
| SCHEMBL20995622 | 0.88 | BTK (0.58) | BTKEGFRITKLCKTEC | |
| SCHEMBL17065743 | 0.88 | BTK (0.75) | BTKEGFRITKLCKTEC | |
| SCHEMBL21030123 | 0.87 | BTK (0.69) | BTKEGFRITKLCKTEC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3481831-B1 | 4-AMINOPYRAZOLO[3,4-D]PYRIMIDINYLAZABICYCLO DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DAEWOONG PHARMACEUTICAL CO LTD (KR) | 2023-09-06 | — | — | EP | disclosed |
| US-10399988-B2 | 4-aminopyrazolo[3,4-d]pyrimidinylazabicyclo derivatives and pharmaceutical composition comprising the same | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2019-09-03 | — | — | US | disclosed |
| US-20190161488-A1 | Novel 4-aminopyrazolo[3,4-d]pyrimidinylazabicyclo Derivatives and Pharmaceutical Composition Comprising the Same | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2019-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10399988-B2 | 4-aminopyrazolo[3,4-d]pyrimidinylazabicyclo derivatives and pharmaceutical composition comprising the same | ITK, BTK, TYK2 | BTK 2/4885EGFR 831/4885ITK 1/4885 |
| US-20190161488-A1 | Novel 4-aminopyrazolo[3,4-d]pyrimidinylazabicyclo Derivatives and Pharmaceutical Composition Comprising the Same | BTK, ITK, TYK2 | BTK 1/4885EGFR 857/4885ITK 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.