Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | MAOA | P21397 | 5/20 | 0.40 |
| ▸ | MAOB | P27338 | 5/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | OGG1 | O15527 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9897381 | 1.00 | GAA (0.45) | GAAALDH1A1MAPTMAOAMAOB | |
| SCHEMBL15519424 | 1.00 | GAA (0.45) | GAAALDH1A1MAPTMAOAMAOB | |
| SCHEMBL1160567 | 1.00 | GAA (0.45) | GAAALDH1A1MAPTMAOAMAOB | |
| SCHEMBL9897387 | 1.00 | GAA (0.45) | GAAALDH1A1MAPTMAOAMAOB | |
| SCHEMBL15519422 | 1.00 | GAA (0.45) | GAAALDH1A1MAPTMAOAMAOB | |
| SCHEMBL9897385 | 1.00 | GAA (0.45) | GAAALDH1A1MAPTMAOAMAOB | |
| SCHEMBL1160571 | 1.00 | GAA (0.45) | GAAALDH1A1MAPTMAOAMAOB | |
| SCHEMBL1160569 | 1.00 | GAA (0.45) | GAAALDH1A1MAPTMAOAMAOB | |
| SCHEMBL9920362 | 1.00 | GAA (0.45) | GAAALDH1A1MAPTMAOAMAOB | |
| SCHEMBL1160570 | 1.00 | GAA (0.45) | GAAALDH1A1MAPTMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019104030-A1 | TETRAHYDRONAPHTHALENE DERIVATIVES USEFUL AS NRF2 ACTIVATORS | BIOGEN MA INC. (US) | 2019-05-31 | — | — | WO | disclosed |