Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.52 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28014492 | 0.85 | MEN1 (0.43) | KMT2AMEN1POLBLMNAPLIN1 | |
| SCHEMBL11263712 | 0.85 | KMT2A (0.49) | KMT2AMEN1POLBLMNAPLIN1 | |
| SCHEMBL27678942 | 0.85 | KMT2A (0.50) | KMT2AMEN1POLBLMNAPLIN1 | |
| SCHEMBL21034066 | 0.81 | KMT2A (0.49) | KMT2AMEN1POLBLMNAPLIN1 | |
| SCHEMBL22283800 | 0.79 | MEN1 (0.49) | KMT2AMEN1POLBLMNAPLIN1 | |
| SCHEMBL22144400 | 0.79 | MEN1 (0.49) | KMT2AMEN1POLBLMNAPLIN1 | |
| SCHEMBL7637124 | 0.78 | PTGS1 (0.53) | KMT2AMEN1POLBLMNANPSR1 | |
| SCHEMBL28303418 | 0.78 | MEN1 (0.49) | KMT2AMEN1POLBLMNAPLIN1 | |
| SCHEMBL2003346 | 0.77 | MEN1 (0.50) | KMT2AMEN1POLBLMNAPLIN1 | |
| SCHEMBL7636543 | 0.77 | MEN1 (0.54) | KMT2AMEN1POLBMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019101144-A1 | SELECTIVE MCL-1 INHIBITOR AND PREPARATION AND USE THEREOF | 北京赛林泰医药技术有限公司 | 2019-05-31 | — | — | WO | disclosed |