Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 14/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.60 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13713606 | 0.92 | HDAC1 (0.62) | HDAC1HDAC2HDAC3NCOR2 | |
| SCHEMBL210309 | 0.91 | HDAC1 (0.59) | HDAC1HDAC2HDAC3NCOR2 | |
| SCHEMBL8280032 | 0.90 | HDAC1 (0.58) | HDAC1HDAC2HDAC3NCOR2 | |
| SCHEMBL210545 | 0.88 | HDAC1 (0.56) | HDAC1HDAC2HDAC3NCOR2 | |
| SCHEMBL209922 | 0.87 | HDAC1 (0.60) | HDAC1HDAC2HDAC3NCOR2 | |
| SCHEMBL209821 | 0.86 | HDAC1 (0.67) | HDAC1HDAC2HDAC3NCOR2 | |
| SCHEMBL211202 | 0.85 | HDAC1 (0.69) | HDAC1HDAC2HDAC3NCOR2RAB9A | |
| SCHEMBL213411 | 0.85 | HDAC1 (0.67) | HDAC1HDAC2HDAC3NCOR2 | |
| SCHEMBL210937 | 0.85 | HDAC1 (0.54) | HDAC1HDAC2HDAC3NCOR2 | |
| SCHEMBL211488 | 0.85 | HDAC1 (0.61) | HDAC1HDAC2HDAC3NCOR2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088805-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2012-01-03 | — | — | US | disclosed |
| US-20070213330-A1 | Anticancer agents; antiproliferative agents | METHYLGENE INC. (CA) | 2007-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213330-A1 | Anticancer agents; antiproliferative agents | HDAC1, HDAC11, HDAC5 | HDAC1 1/4885HDAC2 10/4885HDAC3 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.