Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.38 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.38 |
| ▸ | PTPRC | P08575 | 1/20 | 0.38 |
| ▸ | PTPRG | P23470 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30634084 | 1.00 | POLB (0.52) | POLBMAPTGAAPKMEGFR | |
| SCHEMBL30484939 | 0.79 | POLB (0.52) | POLBMAPTGAAPKMSLC6A4 | |
| SCHEMBL1118636 | 0.79 | POLB (0.52) | POLBMAPTGAAPKMSLC6A4 | |
| SCHEMBL21048059 | 0.79 | POLB (0.52) | POLBMAPTGAAPKMEGFR | |
| SCHEMBL30634086 | 0.79 | POLB (0.52) | POLBMAPTGAAPKMEGFR | |
| SCHEMBL9431344 | 0.75 | POLB (0.47) | POLBMAPTEGFRKMT2AMEN1 | |
| SCHEMBL28801720 | 0.75 | PTPRG (0.58) | POLBMAPTGAAPKMKMT2A | |
| SCHEMBL8373225 | 0.73 | POLB (0.53) | POLBMAPTGAAPKMKMT2A | |
| SCHEMBL943207 | 0.72 | TAAR1 (0.34) | MAPTGAAKMT2AMEN1 | |
| SCHEMBL17712199 | 0.71 | POLB (0.47) | POLBMAPTGAAPKMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12479818-B2 | Treatment of fibrosis with IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2025-11-25 | — | — | US | disclosed |
| US-12404248-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2025-09-02 | — | — | US | disclosed |
| EP-3707126-B1 | IRE1 SMALL MOLECULE INHIBITORS | UNIV CORNELL (US) | 2025-05-14 | — | — | EP | disclosed |
| US-20240425477-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2024-12-26 | — | — | US | disclosed |
| EP-4201924-B1 | IRE1 SMALL MOLECULE INHIBITORS | UNIV CORNELL (US) | 2024-10-23 | — | — | EP | disclosed |
| US-20240287004-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2024-08-29 | — | — | US | disclosed |
| US-12071424-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2024-08-27 | — | — | US | disclosed |
| US-11945784-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2024-04-02 | — | — | US | disclosed |
| EP-3891130-B1 | IRE1 SMALL MOLECULE INHIBITORS | UNIV CORNELL (US) | 2023-10-25 | — | — | EP | disclosed |
| EP-3891130-B1 | IRE1 SMALL MOLECULE INHIBITORS | UNIV CORNELL (US) | 2023-10-25 | — | — | EP | disclosed |
| US-20200392106-A1 | IRE1 Small Molecule Inhibitors | CORNELL UNIVERSITY | 2020-12-17 | — | — | US | disclosed |
| WO-2020232401-A1 | COMBINATION THERAPIES WITH IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY (US) | 2020-11-19 | — | — | WO | disclosed |
| WO-2020232403-A1 | TREATMENT OF FIBROSIS WITH IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY (US) | 2020-11-19 | — | — | WO | disclosed |
| EP-3707126-A1 | IRE1 SMALL MOLECULE INHIBITORS | Cornell University (US) | 2020-09-16 | — | — | EP | disclosed |
| US-10745379-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2020-08-18 | — | — | US | disclosed |
| US-10745379-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2020-08-18 | — | — | US | disclosed |
| WO-2020117634-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY (US) | 2020-06-11 | — | — | WO | disclosed |
| WO-2020117634-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY (US) | 2020-06-11 | — | — | WO | disclosed |
| US-20190169160-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2019-06-06 | — | — | US | disclosed |
| US-20190169160-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2019-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240425477-A1 | IRE1 SMALL MOLECULE INHIBITORS | XBP1, ERN2, ERN1 | POLB 2859/4885MAPT 3493/4885GAA 1747/4885 |
| US-20200392106-A1 | IRE1 Small Molecule Inhibitors | XBP1, ERN2, ERN1 | POLB 2859/4885MAPT 3493/4885GAA 1747/4885 |
| US-11945784-B2 | IRE1 small molecule inhibitors | XBP1, ERN2, ERN1 | POLB 2859/4885MAPT 3493/4885GAA 1747/4885 |
| US-12071424-B2 | IRE1 small molecule inhibitors | XBP1, ERN2, ERN1 | POLB 2859/4885MAPT 3493/4885GAA 1747/4885 |
| US-12479818-B2 | Treatment of fibrosis with IRE1 small molecule inhibitors | XBP1, DDIT3, HSP90B1 | POLB 3286/4885MAPT 4228/4885GAA 2332/4885 |
| US-20240287004-A1 | IRE1 SMALL MOLECULE INHIBITORS | XBP1, ERN2, ERN1 | POLB 2859/4885MAPT 3493/4885GAA 1747/4885 |
| US-20190169160-A1 | IRE1 SMALL MOLECULE INHIBITORS | XBP1, ERN2, ERN1 | POLB 2859/4885MAPT 3493/4885GAA 1747/4885 |
| US-12404248-B2 | IRE1 small molecule inhibitors | XBP1, ERN2, ERN1 | POLB 2859/4885MAPT 3493/4885GAA 1747/4885 |
| US-10745379-B2 | IRE1 small molecule inhibitors | XBP1, ERN2, ERN1 | POLB 2859/4885MAPT 3493/4885GAA 1747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.