Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 15/20 | 0.70 |
| ▸ | PIK3CD | O00329 | 12/20 | 0.70 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.70 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.70 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.70 |
| ▸ | PRKDC | P78527 | 9/20 | 0.70 |
| ▸ | ABL1 | P00519 | 8/20 | 0.70 |
| ▸ | EGFR | P00533 | 8/20 | 0.70 |
| ▸ | HCK | P08631 | 8/20 | 0.70 |
| ▸ | KDR | P35968 | 8/20 | 0.70 |
| ▸ | MTOR | P42345 | 8/20 | 0.70 |
| ▸ | EPHB4 | P54760 | 8/20 | 0.70 |
| ▸ | PI4KB | Q9UBF8 | 7/20 | 0.70 |
| ▸ | BTK | Q06187 | 4/20 | 0.65 |
| ▸ | LCK | P06239 | 3/20 | 0.58 |
| ▸ | CSK | P41240 | 2/20 | 0.58 |
| ▸ | LYN | P07948 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3610794 | 0.90 | PIK3CD (0.75) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL16655530 | 0.78 | PIK3CD (1.00) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL3616908 | 0.77 | EGFR (1.00) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL3612927 | 0.77 | PIK3CD (1.00) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL6430687 | 0.77 | BTK (0.82) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL16655325 | 0.77 | PIK3CD (1.00) | PIK3CDBTK | |
| SCHEMBL15613529 | 0.77 | BTK (0.61) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL16886156 | 0.76 | BTK (0.60) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL24041322 | 0.76 | BTK (0.78) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL16886196 | 0.75 | BTK (0.62) | SRCPIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2551270-B1 | PYRAZOLOPYRIMIDINE DERIVATIVES FOR USE AS PI3 KINASE ANTAGONISTS | UNIV CALIFORNIA (US) | 2019-06-12 | — | — | EP | disclosed |