Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | MDH2 | P40926 | 1/20 | 0.32 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.32 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.32 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.32 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17542975 | 0.94 | PTGDR2 (0.34) | KCNH2PTGDR2FFAR4CACNA1GKDM4E | |
| SCHEMBL17543278 | 0.92 | KMT2A (0.38) | HTTMEN1POLBKMT2A | |
| SCHEMBL17542910 | 0.92 | PTGDR2 (0.34) | KCNH2PTGDR2FFAR4CACNA1GKDM4E | |
| SCHEMBL17544008 | 0.91 | DDB1 (0.38) | PTGDR2TP53THRBPTGER2PARP1 | |
| SCHEMBL17542917 | 0.90 | CHRM4 (0.38) | KCNH2PTGDR2CACNA1GKDM4EHTT | |
| SCHEMBL17543674 | 0.90 | PTGDR2 (0.39) | KCNH2PTGDR2FFAR4HTTTP53 | |
| SCHEMBL17543094 | 0.89 | TP53 (0.35) | KCNH2PTGDR2CACNA1GKDM4EHTT | |
| SCHEMBL17542704 | 0.89 | PTGDR2 (0.34) | KCNH2PTGDR2FFAR4CACNA1GKDM4E | |
| SCHEMBL17543294 | 0.89 | KDM4E (0.34) | KCNH2PTGDR2FFAR4CACNA1GKDM4E | |
| SCHEMBL17543858 | 0.89 | GRM2 (0.36) | KCNH2PTGDR2FFAR4CXCR3GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3186240-B1 | HETEROBICYCLIC COMPOUNDS AND THEIR USE FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMA CO LTD (JP) | 2019-06-12 | — | — | EP | disclosed |