Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 20/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18182725 | 1.00 | KDM1A (0.60) | KDM1AHDAC6HDAC1HDAC8HDAC3 | |
| SCHEMBL21088917 | 0.92 | KDM1A (0.57) | KDM1AHDAC6HDAC1HDAC8HDAC3 | |
| SCHEMBL21049041 | 0.90 | KDM1A (0.63) | KDM1AHDAC6HDAC1HDAC8HDAC3 | |
| SCHEMBL18182726 | 0.90 | KDM1A (0.63) | KDM1AHDAC6HDAC1HDAC8HDAC3 | |
| SCHEMBL21088321 | 0.86 | KDM1A (0.61) | KDM1AHDAC6HDAC1HDAC8HDAC3 | |
| SCHEMBL18173038 | 0.84 | KDM1A (0.65) | KDM1AHDAC6HDAC1HDAC8MAOB | |
| SCHEMBL18173033 | 0.84 | KDM1A (0.65) | KDM1AHDAC6HDAC1HDAC8MAOB | |
| SCHEMBL18183183 | 0.82 | KDM1A (0.56) | KDM1AHDAC6HDAC1HDAC8HDAC3 | |
| SCHEMBL18182137 | 0.82 | KDM1A (0.65) | KDM1AHDAC6HDAC1HDAC8HDAC3 | |
| SCHEMBL18182724 | 0.81 | KDM1A (0.67) | KDM1AHDAC6HDAC1HDAC8HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3286172-B1 | LSD1 INHIBITORS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS INC (US) | 2019-06-12 | — | — | EP | disclosed |