Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 9/20 | 0.33 |
| ▸ | KRAS | P01116 | 9/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21050918 | 0.87 | ABL1 (0.36) | KRAS | |
| SCHEMBL21099211 | 0.86 | SMARCA2 (0.37) | — | |
| SCHEMBL21050676 | 0.79 | ABL1 (0.36) | KRAS | |
| SCHEMBL21050677 | 0.79 | ABL1 (0.36) | KRAS | |
| SCHEMBL21050764 | 0.79 | ABL1 (0.36) | KRAS | |
| SCHEMBL21136721 | 0.77 | — | — | |
| SCHEMBL21050944 | 0.76 | ABL1 (0.36) | KRAS | |
| SCHEMBL21050699 | 0.75 | KRAS (0.54) | KRASNFE2L2 | |
| SCHEMBL21050715 | 0.75 | KRAS (0.54) | KRASNFE2L2 | |
| SCHEMBL21050984 | 0.74 | KRAS (0.55) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10597405-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2020-03-24 | — | — | US | disclosed |
| US-20190177338-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2019-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190177338-A1 | CHEMICAL COMPOUNDS | MKI67, CCNI, MCL1 | MDM2 2428/4885KRAS 272/4885NFE2L2 415/4885 |
| US-10597405-B2 | Chemical compounds | MKI67, CCNI, MCL1 | MDM2 2428/4885KRAS 272/4885NFE2L2 415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.