⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22802058 | 0.95 | NPC1 (0.33) | — | |
| SCHEMBL21052022 | 0.86 | MAPT (0.32) | — | |
| SCHEMBL21052032 | 0.83 | FFAR4 (0.35) | — | |
| SCHEMBL21098745 | 0.83 | FFAR4 (0.35) | — | |
| SCHEMBL21052079 | 0.82 | BRD4 (0.33) | — | |
| SCHEMBL21098744 | 0.82 | BRD4 (0.33) | — | |
| SCHEMBL21052173 | 0.81 | MAPT (0.41) | — | |
| SCHEMBL21052171 | 0.78 | NPC1 (0.36) | — | |
| SCHEMBL21098674 | 0.78 | NPC1 (0.36) | — | |
| SCHEMBL21052172 | 0.78 | NPC1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11576981-B2 | Acyl hydrazone linkers, methods and uses thereof | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2023-02-14 | — | — | US | disclosed |
| US-20200397916-A1 | ACYL HYDRAZONE LINKERS, METHODS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2020-12-24 | — | — | US | disclosed |
| EP-3720842-A1 | ACYL HYDRAZONE LINKERS, METHODS AND USES THEREOF | Ontario Institute For Cancer Research (CA) | 2020-10-14 | — | — | EP | disclosed |
| WO-2019109188-A1 | ACYL HYDRAZONE LINKERS, METHODS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2019-06-13 | — | — | WO | disclosed |