Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | FPR2 | P25090 | 2/20 | 0.41 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | VDR | P11473 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21055560 | 1.00 | CYP2D6 (0.53) | CYP2D6SMN1; SMN2HTTCYP3A4CYP2C19 | |
| SCHEMBL21055454 | 0.87 | CYP2D6 (0.52) | CYP2D6SMN1; SMN2CYP2C19CYP1A2MEN1 | |
| SCHEMBL21055453 | 0.87 | CYP2D6 (0.52) | CYP2D6SMN1; SMN2CYP2C19CYP1A2MEN1 | |
| SCHEMBL657896 | 0.86 | CYP2D6 (0.67) | CYP2D6SMN1; SMN2CYP3A4CYP2C19CYP1A2 | |
| SCHEMBL10376015 | 0.86 | CYP2D6 (0.67) | CYP2D6SMN1; SMN2CYP3A4CYP2C19CYP1A2 | |
| SCHEMBL1500377 | 0.82 | CYP2D6 (0.53) | CYP2D6SMN1; SMN2HTTCYP3A4CYP2C19 | |
| SCHEMBL8705318 | 0.82 | CYP2D6 (0.53) | CYP2D6SMN1; SMN2HTTCYP3A4CYP2C19 | |
| SCHEMBL21055393 | 0.81 | CYP2D6 (0.49) | CYP2D6CYP3A4CYP2C19CYP1A2MEN1 | |
| SCHEMBL21055396 | 0.81 | CYP2D6 (0.49) | CYP2D6CYP3A4CYP2C19CYP1A2MEN1 | |
| SCHEMBL718466 | 0.80 | CYP2D6 (0.51) | CYP2D6SMN1; SMN2HTTCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11247990-B1 | Bicyclic fused pyridine compounds as inhibitors of TAM kinases | ARRAY BIOPHARMA INC (US) | 2022-02-15 | — | — | US | disclosed |
| WO-2019113190-A1 | BICYCLIC FUSED PYRIDINE COMPOUNDS AS INHIBITORS OF TAM KINASES | ARRAY BIOPHARMA INC. (US) | 2019-06-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11247990-B1 | Bicyclic fused pyridine compounds as inhibitors of TAM kinases | MAP3K1, MAP3K3, MAP3K2 | CYP2D6 3215/4885SMN1; SMN2 3848/4885HTT 4589/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.