Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.62 |
| ▸ | F11 | P03951 | 3/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.43 |
| ▸ | LIPG | Q9Y5X9 | 6/20 | 0.42 |
| ▸ | LPL | P06858 | 5/20 | 0.42 |
| ▸ | CA1 | P00915 | 6/20 | 0.38 |
| ▸ | CA2 | P00918 | 6/20 | 0.38 |
| ▸ | CA9 | Q16790 | 6/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14898157 | 0.87 | ROCK1 (0.63) | ROCK1F11F2PRSS1PRSS2 | |
| SCHEMBL29897686 | 0.87 | ROCK1 (0.48) | ROCK1F11F2PRSS1PRSS2 | |
| SCHEMBL14710834 | 0.84 | ROCK1 (0.60) | ROCK1F11F2PRSS1PRSS2 | |
| SCHEMBL2950821 | 0.83 | ROCK1 (0.45) | ROCK1F11F2PRSS1PRSS2 | |
| SCHEMBL29279137 | 0.83 | ROCK1 (0.53) | ROCK1F11F2PRSS1PRSS2 | |
| SCHEMBL18643675 | 0.82 | ROCK1 (0.56) | ROCK1F11LIPGLPLCA1 | |
| SCHEMBL12068442 | 0.82 | ROCK1 (0.57) | ROCK1F11F2PRSS1PRSS2 | |
| SCHEMBL29825714 | 0.82 | ROCK1 (0.57) | ROCK1F11F2PRSS1PRSS2 | |
| SCHEMBL30124534 | 0.81 | ROCK1 (0.43) | ROCK1F11F2PRSS1PRSS2 | |
| SCHEMBL3321140 | 0.81 | ROCK1 (0.55) | ROCK1F11F2PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10322130-B2 | Substituted chromenones as modulators of protein kinases | RHIZEN PHARMACEUTICALS SA (CH) | 2019-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10322130-B2 | Substituted chromenones as modulators of protein kinases | MAP3K1, CSNK1A1, MAP3K2 | ROCK1 76/4885F11 1316/4885F2 2293/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.