SCHEMBL21059488

SCHEMBL21059488

CCCc1cc(Cl)ccc1O[C@@H](C)C(=O)O

nearest known ligand 0.62

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.62
HTR2A P28223 1/20 0.62
HTR2C P28335 1/20 0.62
HTR2B P41595 1/20 0.62
SMN1; SMN2 Q16637 1/20 0.52
PTGDR2 Q9Y5Y4 6/20 0.52
PTGDR Q13258 1/20 0.52
PPARG P37231 2/20 0.46
PPARA Q07869 2/20 0.46
ALDH1A1 P00352 2/20 0.43
KDM4E B2RXH2 1/20 0.43
HSD17B10 Q99714 1/20 0.43
LMNA P02545 2/20 0.43
MAPT P10636 2/20 0.43
KMT2A Q03164 2/20 0.43
MEN1 O00255 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
HPGD P15428 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21059489 1.00 TSHR (0.62) TSHRHTR2AHTR2CHTR2BSMN1; SMN2
SCHEMBL30287862 0.99 TSHR (0.61) TSHRHTR2AHTR2CHTR2BSMN1; SMN2
SCHEMBL21059453 0.90 TSHR (0.68) TSHRHTR2AHTR2CHTR2BSMN1; SMN2
SCHEMBL21059454 0.90 TSHR (0.68) TSHRHTR2AHTR2CHTR2BSMN1; SMN2
SCHEMBL13603780 0.87 TSHR (0.68) TSHRHTR2AHTR2CHTR2BSMN1; SMN2
SCHEMBL11094619 0.82 PPARA (0.43) TSHRHTR2AHTR2CHTR2BSMN1; SMN2
SCHEMBL1332738 0.81 TSHR (0.59) TSHRHTR2AHTR2CHTR2BPTGDR2
SCHEMBL11835348 0.79 TSHR (0.57) TSHRHTR2AHTR2CHTR2BSMN1; SMN2
(S)-Dichlorprop SCHEMBL1535831 0.79 TSHR (0.73) TSHRHTR2AHTR2CHTR2BSMN1; SMN2
Rac-Dichlorprop SCHEMBL54510 0.79 TSHR (0.73) TSHRHTR2AHTR2CHTR2BSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111491628-B Phenoxy acids for the treatment of neuromuscular disorders NMD制药股份公司 2023-10-13 CN claimed
EP-3723746-B1 PHENOXY ACIDS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS NMD PHARMA AS (DK) 2022-02-23 EP claimed
EP-3723746-A1 PHENOXY ACIDS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS NMD Pharma A/S (DK) 2020-10-21 EP claimed
CN-111491628-A Phenoxy acids for the treatment of neuromuscular disorders NMD制药股份公司 2020-08-04 CN claimed
WO-2019115780-A1 PHENOXY ACIDS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS NMD PHARMA A/S (DK) 2019-06-20 WO claimed
US-20190183812-A1 Compounds For The Treatment Of Neuromuscular Disorders NMD PHARMA A/S (DK) 2019-06-20 US claimed
US-20190185409-A1 Compounds For The Treatment Of Neuromuscular Disorders NMD PHARMA APS (DK) 2019-06-20 US claimed
CN-111491628-B Phenoxy acids for the treatment of neuromuscular disorders NMD制药股份公司 2023-10-13 CN disclosed
US-11591284-B2 Compounds for the treatment of neuromuscular disorders NMD PHARMA A/S (DK) 2023-02-28 US disclosed
EP-3723746-B1 PHENOXY ACIDS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS NMD PHARMA AS (DK) 2022-02-23 EP disclosed
EP-3723746-A1 PHENOXY ACIDS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS NMD Pharma A/S (DK) 2020-10-21 EP disclosed
CN-111491628-A Phenoxy acids for the treatment of neuromuscular disorders NMD制药股份公司 2020-08-04 CN disclosed
WO-2019115780-A1 PHENOXY ACIDS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS NMD PHARMA A/S (DK) 2019-06-20 WO disclosed
US-20190185409-A1 Compounds For The Treatment Of Neuromuscular Disorders NMD PHARMA APS (DK) 2019-06-20 US disclosed
US-20190183812-A1 Compounds For The Treatment Of Neuromuscular Disorders NMD PHARMA A/S (DK) 2019-06-20 US disclosed
US-20190185409-A1 Compounds For The Treatment Of Neuromuscular Disorders NMD PHARMA APS (DK) 2019-06-20 US disclosed
US-20190183812-A1 Compounds For The Treatment Of Neuromuscular Disorders NMD PHARMA A/S (DK) 2019-06-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190185409-A1 Compounds For The Treatment Of Neuromuscular Disorders CPT1B, CLCN2, CACNB1 TSHR 3912/4885HTR2A 3420/4885HTR2C 3861/4885
US-20190183812-A1 Compounds For The Treatment Of Neuromuscular Disorders RYR1, CACNB1, RYR2 TSHR 3626/4885HTR2A 3861/4885HTR2C 4504/4885
US-11591284-B2 Compounds for the treatment of neuromuscular disorders RYR1, CACNB1, CACNA1S TSHR 4324/4885HTR2A 3734/4885HTR2C 4093/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.