Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pf-00562271. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 known ✓ | Q05397 | 19/20 | 0.99 |
| ▸ | PTK2B | Q14289 | 10/20 | 0.99 |
| ▸ | AURKA | O14965 | 2/20 | 0.99 |
| ▸ | PLK4 | O00444 | 1/20 | 0.99 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.99 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.99 |
| ▸ | JAK2 | O60674 | 1/20 | 0.99 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.99 |
| ▸ | STK16 | O75716 | 1/20 | 0.99 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.99 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.99 |
| ▸ | PAK4 | O96013 | 1/20 | 0.99 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.99 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.99 |
| ▸ | PRKCG | P05129 | 1/20 | 0.99 |
| ▸ | INSR | P06213 | 1/20 | 0.99 |
| ▸ | LCK | P06239 | 1/20 | 0.99 |
| ▸ | FYN | P06241 | 1/20 | 0.99 |
| ▸ | CDK1 | P06493 | 1/20 | 0.99 |
| ▸ | LYN | P07948 | 1/20 | 0.99 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pf-00562271 SCHEMBL29496512 | 1.00 | PTK2 (0.99) | PTK2PTK2BAURKAPLK4PDPK1 | |
| Pf-00562271 SCHEMBL1206959 | 0.99 | PTK2 (1.00) | PTK2PTK2BAURKAPLK4PDPK1 | |
| Pf-00562271 SCHEMBL29381854 | 0.99 | PTK2 (1.00) | PTK2PTK2BAURKAPLK4PDPK1 | |
| Pf-00562271 SCHEMBL29637167 | 0.99 | PTK2 (1.00) | PTK2PTK2BAURKAPLK4PDPK1 | |
| SCHEMBL5185817 | 0.94 | PTK2 (0.89) | PTK2PTK2BAURKAPLK4PDPK1 | |
| Pf-00562271 SCHEMBL20471937 | 0.93 | PTK2 (1.00) | PTK2PTK2BAURKAPLK4PDPK1 | |
| SCHEMBL5217154 | 0.93 | PTK2 (1.00) | PTK2PTK2BAURKAPLK4PDPK1 | |
| SCHEMBL5501091 | 0.91 | PTK2 (0.84) | PTK2PTK2BAURKAPLK4PDPK1 | |
| SCHEMBL5504547 | 0.91 | PTK2 (0.84) | PTK2PTK2BAURKAPLK4PDPK1 | |
| SCHEMBL5498812 | 0.90 | PTK2 (0.83) | PTK2PTK2BAURKAPLK4PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4640238-A1 | THERAPEUTIC AGENT FOR PULMONARY DISEASE, HEPATIC DISEASE OR RENAL DISEASE, WHICH CONTAINS PGAM-CHK1 BINDING INHIBITOR | Kyoto University (JP) | 2025-10-29 | — | — | EP | disclosed |
| EP-4537844-A1 | PROPHYLACTIC OR THERAPEUTIC AGAINST EXACERBATION OR RECURRENCE OF CANCER, AND SCREENING METHOD THEREFOR | Keio University (JP) | 2025-04-16 | — | — | EP | disclosed |
| CN-119604307-A | Preventive or therapeutic agent for recurrence or recurrence of cancer and screening method therefor | 庆应义塾 | 2025-03-11 | — | — | CN | disclosed |
| US-20250003952-A1 | SENOLYTIC DRUG SCREENING METHOD AND SENOLYTIC DRUG | KYOTO UNIVERSITY (JP) | 2025-01-02 | — | — | US | disclosed |
| EP-4400117-A1 | SENOLYTIC DRUG SCREENING METHOD AND SENOLYTIC DRUG | Kyoto University (JP) | 2024-07-17 | — | — | EP | disclosed |
| WO-2024135719-A1 | THERAPEUTIC AGENT FOR PULMONARY DISEASE, HEPATIC DISEASE OR RENAL DISEASE, WHICH CONTAINS PGAM-CHK1 BINDING INHIBITOR | 国立大学法人京都大学 | 2024-06-27 | — | — | WO | disclosed |
| CN-117915953-A | Method for screening senescent cell scavenger and senescent cell scavenger | 国立大学法人京都大学 | 2024-04-19 | — | — | CN | disclosed |
| WO-2023238939-A1 | PROPHYLACTIC OR THERAPEUTIC AGAINST EXACERBATION OR RECURRENCE OF CANCER, AND SCREENING METHOD THEREFOR | 慶應義塾 | 2023-12-14 | — | — | WO | disclosed |
| WO-2023038027-A1 | SENOLYTIC DRUG SCREENING METHOD AND SENOLYTIC DRUG | 国立大学法人京都大学 | 2023-03-16 | — | — | WO | disclosed |
| WO-2019117813-A1 | FOCAL ADHESION KINASE TARGETED THERAPEUTICS FOR THE TREATMENT OF GLAUCOMA AND FIBROSIS | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2019-06-20 | — | — | WO | disclosed |