Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 15/20 | 0.47 |
| ▸ | JAK1 | P23458 | 14/20 | 0.47 |
| ▸ | JAK2 | O60674 | 12/20 | 0.47 |
| ▸ | TYK2 | P29597 | 4/20 | 0.46 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3403885 | 0.85 | JAK2 (0.55) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL2104973 | 0.81 | JAK2 (0.48) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL2106504 | 0.81 | JAK2 (0.55) | JAK3JAK1JAK2TYK2NUDT1 | |
| SCHEMBL2104906 | 0.81 | JAK2 (0.55) | JAK3JAK1JAK2TYK2NUDT1 | |
| SCHEMBL3430719 | 0.81 | JAK2 (0.55) | JAK3JAK1JAK2TYK2NUDT1 | |
| SCHEMBL2105190 | 0.81 | JAK2 (0.60) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL2104887 | 0.80 | JAK2 (0.54) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL2106071 | 0.80 | JAK2 (0.51) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL2107295 | 0.80 | JAK2 (0.51) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL2106244 | 0.80 | JAK2 (0.49) | JAK3JAK1JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163767-B2 | Heterocyclic Janus Kinase 3 inhibitors | ASTELLAS PHARMA INC. (JP) | 2012-04-24 | — | — | US | disclosed |