Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15861680 | 0.84 | NR1H2 (0.50) | NR1H2USP2SMN1; SMN2NAMPTMEN1 | |
| SCHEMBL21640603 | 0.80 | NR1H2 (0.53) | NR1H2USP2SMN1; SMN2NAMPTMEN1 | |
| SCHEMBL16414679 | 0.79 | NR1H2 (0.46) | NR1H2USP2SMN1; SMN2NAMPTMEN1 | |
| SCHEMBL25181574 | 0.78 | NR1H2 (0.54) | NR1H2USP2SMN1; SMN2NAMPTMEN1 | |
| Lithium Ion SCHEMBL21063447 | 0.76 | NR1H2 (0.46) | NR1H2USP2SMN1; SMN2NAMPTMEN1 | |
| SCHEMBL21640265 | 0.76 | NR1H2 (0.54) | NR1H2USP2SMN1; SMN2NAMPTMEN1 | |
| SCHEMBL4184533 | 0.74 | NR1H2 (0.53) | NR1H2USP2SMN1; SMN2NAMPTMEN1 | |
| Lithium Ion SCHEMBL21063390 | 0.73 | NR1H2 (0.53) | NR1H2USP2SMN1; SMN2NAMPTMEN1 | |
| SCHEMBL26049286 | 0.73 | NR1H2 (0.51) | NR1H2USP2SMN1; SMN2NAMPTMEN1 | |
| SCHEMBL20635761 | 0.73 | NR1H2 (0.51) | NR1H2USP2SMN1; SMN2NAMPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019118612-A1 | TARGETING COMPOUNDS | ZAFGEN, INC. (US) | 2019-06-20 | — | — | WO | disclosed |