Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 14/20 | 0.65 |
| ▸ | HCRTR1 | O43613 | 12/20 | 0.65 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21065207 | 1.00 | HCRTR2 (0.65) | HCRTR2HCRTR1USP30UCHL1FFAR4 | |
| SCHEMBL3853950 | 0.91 | HCRTR1 (0.64) | HCRTR2HCRTR1USP30UCHL1POLB | |
| SCHEMBL3853946 | 0.91 | HCRTR1 (0.64) | HCRTR2HCRTR1USP30UCHL1POLB | |
| SCHEMBL21065161 | 0.89 | HCRTR1 (0.65) | HCRTR2HCRTR1 | |
| SCHEMBL21065162 | 0.89 | HCRTR1 (0.65) | HCRTR2HCRTR1 | |
| SCHEMBL3916610 | 0.87 | HCRTR1 (0.53) | HCRTR2HCRTR1USP30UCHL1POLB | |
| SCHEMBL3916612 | 0.87 | HCRTR1 (0.53) | HCRTR2HCRTR1USP30UCHL1POLB | |
| SCHEMBL3852302 | 0.86 | HCRTR1 (0.50) | HCRTR2HCRTR1USP30UCHL1POLB | |
| SCHEMBL3852298 | 0.86 | HCRTR1 (0.50) | HCRTR2HCRTR1USP30UCHL1POLB | |
| SCHEMBL3922427 | 0.85 | HCRTR1 (0.49) | HCRTR2HCRTR1USP30UCHL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2906553-B1 | OREXIN RECEPTOR ANTAGONISTS WHICH ARE [ORTHO BI (HETERO )ARYL]-[2-(META BI (HETERO)ARYL)-PYRROLIDIN-1-YL]-METHANONE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2019-06-26 | — | — | EP | disclosed |