Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | APP | P05067 | 4/20 | 0.55 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.49 |
| ▸ | ACE | P12821 | 1/20 | 0.49 |
| ▸ | CTSS | P25774 | 2/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13731756 | 1.00 | ATM (0.59) | ATMAPPKLK5ACECTSS | |
| SCHEMBL13738012 | 1.00 | ATM (0.59) | ATMAPPKLK5ACECTSS | |
| SCHEMBL21501009 | 0.85 | ATM (0.67) | ATMAPPKLK5ACECTSS | |
| SCHEMBL21501008 | 0.85 | ATM (0.67) | ATMAPPKLK5ACECTSS | |
| SCHEMBL271498 | 0.81 | ATM (0.64) | ATMAPPACECTSSCTSL | |
| SCHEMBL273008 | 0.81 | ATM (0.64) | ATMAPPACECTSSCTSL | |
| SCHEMBL271499 | 0.81 | ATM (0.64) | ATMAPPACECTSSCTSL | |
| SCHEMBL6312621 | 0.80 | ATM (0.70) | ATMAPPKLK5ACECTSS | |
| SCHEMBL273006 | 0.80 | ATM (0.70) | ATMAPPKLK5ACECTSS | |
| SCHEMBL30334225 | 0.80 | ATM (0.70) | ATMAPPKLK5ACECTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3501546-A2 | CYSTEINE DRUG CONJUGATES AND USE OF SAME | Seattle Genetics, Inc. (US) | 2019-06-26 | — | — | EP | disclosed |
| CN-106117312-A | New bonding agent drug conjugate (ADC) and application thereof | 西雅图基因公司 | 2016-11-16 | — | — | CN | disclosed |
| CN-104254342-A | FGRF antibody drug conjugates (ADCs) and the use thereof | SEATTLE GENETICS INC | 2014-12-31 | — | — | CN | disclosed |
| CN-103826661-A | Novel binding agent-drug conjugates (ADCs) and uses thereof | SEATTLE GENETICS INC | 2014-05-28 | — | — | CN | disclosed |
| CN-103764170-A | Novel binder-drug conjugates (ADCs) and their use | SEATTLE GENETICS INC | 2014-04-30 | — | — | CN | disclosed |