SCHEMBL21067446

SCHEMBL21067446

CCC(N)C(=O)N1CCC[C@H]1C(=O)NCc1cccc(Cl)c1

nearest known ligand 0.63

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
F2 P00734 13/20 0.63
P2RX7 Q99572 1/20 0.54
F10 P00742 2/20 0.52
PRSS1 P07477 2/20 0.52
PRSS2 P07478 2/20 0.52
PRSS3 P35030 2/20 0.52
EP300 Q09472 1/20 0.49
MEN1 O00255 1/20 0.49
KMT2A Q03164 1/20 0.49
F12 P00748 1/20 0.49
F7 P08709 1/20 0.49
POLB P06746 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21067443 1.00 F2 (0.63) F2P2RX7F10PRSS1PRSS2
SCHEMBL15077016 1.00 F2 (0.63) F2P2RX7F10PRSS1PRSS2
SCHEMBL21067304 0.90 F2 (0.61) F2P2RX7F10PRSS1PRSS2
SCHEMBL21067308 0.90 F2 (0.61) F2P2RX7F10PRSS1PRSS2
SCHEMBL15077020 0.90 F2 (0.61) F2P2RX7F10PRSS1PRSS2
SCHEMBL15077017 0.89 F2 (0.69) F2POLB
SCHEMBL21067749 0.89 F2 (0.69) F2POLB
SCHEMBL21067746 0.89 F2 (0.69) F2POLB
SCHEMBL21067851 0.87 F2 (0.67) F2P2RX7F10PRSS1PRSS2
SCHEMBL21067854 0.87 F2 (0.67) F2P2RX7F10PRSS1PRSS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11446398-B2 Regulated biocircuit systems OBSIDIAN THERAPEUTICS, INC. (US) 2022-09-20 US disclosed
US-20210254056-A1 IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS CAMP4 THERAPEUTICS CORPORATION 2021-08-19 US disclosed
US-20190192691-A1 REGULATED BIOCIRCUIT SYSTEMS OBSIDIAN THERAPEUTICS, INC. 2019-06-27 US disclosed