Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 15/20 | 1.00 |
| ▸ | CHEK2 | O96017 | 11/20 | 1.00 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4736365 | 1.00 | CHEK1 (1.00) | CHEK1CHEK2PRKCQMAP4K1ADORA2A | |
| SCHEMBL14162751 | 0.90 | CHEK1 (0.82) | CHEK1CHEK2PRKCQMAP4K1LRRK2 | |
| SCHEMBL14162747 | 0.90 | CHEK1 (0.82) | CHEK1CHEK2PRKCQMAP4K1AKT2 | |
| SCHEMBL14162776 | 0.89 | CHEK1 (0.80) | CHEK1CHEK2LMNAMAPT | |
| SCHEMBL14162742 | 0.89 | CHEK1 (0.79) | CHEK1CHEK2PRKCQMAP4K1LRRK2 | |
| SCHEMBL14162752 | 0.87 | CHEK1 (0.77) | CHEK1CHEK2PRKCQMAP4K1AKT2 | |
| SCHEMBL14163052 | 0.87 | CHEK1 (0.77) | CHEK1CHEK2PRKCQMAP4K1 | |
| SCHEMBL14162771 | 0.86 | CHEK1 (1.00) | CHEK1CHEK2PRKCQMAP4K1AKT2 | |
| SCHEMBL14162774 | 0.86 | CHEK1 (0.74) | CHEK1CHEK2PRKCQMAP4K1 | |
| SCHEMBL14162749 | 0.85 | CHEK1 (0.74) | CHEK1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210254056-A1 | IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS | CAMP4 THERAPEUTICS CORPORATION | 2021-08-19 | — | — | US | disclosed |
| US-20190192691-A1 | REGULATED BIOCIRCUIT SYSTEMS | OBSIDIAN THERAPEUTICS, INC. | 2019-06-27 | — | — | US | disclosed |