Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 20/20 | 0.66 |
| ▸ | MAPK8 | P45983 | 17/20 | 0.66 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.65 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.65 |
| ▸ | INSR | P06213 | 1/20 | 0.65 |
| ▸ | CDC7 | O00311 | 1/20 | 0.59 |
| ▸ | PLK4 | O00444 | 1/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.59 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.59 |
| ▸ | PRKCG | P05129 | 1/20 | 0.59 |
| ▸ | ROS1 | P08922 | 1/20 | 0.59 |
| ▸ | PIM1 | P11309 | 1/20 | 0.59 |
| ▸ | FER | P16591 | 1/20 | 0.59 |
| ▸ | LTK | P29376 | 1/20 | 0.59 |
| ▸ | AXL | P30530 | 1/20 | 0.59 |
| ▸ | GRK5 | P34947 | 1/20 | 0.59 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.59 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.59 |
| ▸ | CLK2 | P49760 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29395565 | 1.00 | IGF1R (0.66) | IGF1RMAPK8MAPK10ALKINSR | |
| SCHEMBL12429391 | 0.87 | GRK5 (0.73) | IGF1RGRK5PTK2 | |
| SCHEMBL12430015 | 0.82 | IGF1R (0.81) | IGF1RMAPK8MAPK10ALKINSR | |
| SCHEMBL12429328 | 0.82 | GRK5 (0.69) | IGF1RMAPK8GRK5 | |
| SCHEMBL12429667 | 0.80 | IGF1R (0.70) | IGF1RMAPK8MAPK10ALKINSR | |
| SCHEMBL12430019 | 0.80 | IGF1R (0.77) | IGF1RMAPK8MAPK10ALKINSR | |
| SCHEMBL12429698 | 0.79 | IGF1R (0.69) | IGF1RMAPK8MAPK10ALKINSR | |
| SCHEMBL12429671 | 0.79 | IGF1R (0.75) | IGF1RMAPK8MAPK10ALKINSR | |
| SCHEMBL12429443 | 0.79 | IGF1R (0.77) | IGF1RMAPK8MAPK10ALKINSR | |
| SCHEMBL11919217 | 0.79 | IGF1R (1.00) | IGF1RMAPK8MAPK10ALKINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210254056-A1 | IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS | CAMP4 THERAPEUTICS CORPORATION | 2021-08-19 | — | — | US | disclosed |
| US-20190192691-A1 | REGULATED BIOCIRCUIT SYSTEMS | OBSIDIAN THERAPEUTICS, INC. | 2019-06-27 | — | — | US | disclosed |