Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 11/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17061883 | 0.91 | SCN9A (0.58) | SCN9ASMN1; SMN2L3MBTL1PDE2A | |
| SCHEMBL17062104 | 0.91 | SCN9A (0.58) | SCN9ASMN1; SMN2L3MBTL1PDE2A | |
| SCHEMBL17061886 | 0.91 | SCN9A (0.58) | SCN9ASMN1; SMN2L3MBTL1PDE2A | |
| SCHEMBL17069306 | 0.90 | SCN9A (0.57) | SCN9ASMN1; SMN2L3MBTL1PDE2A | |
| SCHEMBL17428300 | 0.88 | SCN9A (0.53) | SCN9APDE2A | |
| SCHEMBL19064854 | 0.88 | SCN9A (0.53) | SCN9APDE2A | |
| SCHEMBL17423088 | 0.88 | SCN9A (0.53) | SCN9APDE2A | |
| SCHEMBL21075440 | 0.87 | SCN9A (0.52) | SCN9APDE2A | |
| SCHEMBL21825365 | 0.86 | SCN9A (0.56) | SCN9AMEN1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL16771017 | 0.85 | SCN9A (0.74) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166939-B1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH INC (US) | 2019-06-05 | — | — | EP | disclosed |