Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 11/20 | 0.77 |
| ▸ | SCN7A | Q01118 | 9/20 | 0.54 |
| ▸ | SCN5A | Q14524 | 8/20 | 0.53 |
| ▸ | SCN1A | P35498 | 1/20 | 0.50 |
| ▸ | SCN4A | P35499 | 1/20 | 0.50 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.50 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.50 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.50 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17423035 | 0.88 | SCN9A (0.73) | SCN9ASCN7ASCN5ASCN1ASCN4A | |
| SCHEMBL17428650 | 0.87 | SCN9A (1.00) | SCN9ASCN7ASCN5ASCN1ASCN4A | |
| SCHEMBL21075401 | 0.86 | SCN7A (0.68) | SCN9ASCN7ASCN5ASCN1ASCN4A | |
| SCHEMBL19075796 | 0.85 | SCN9A (0.85) | SCN9ASCN7ASCN5ASCN1ASCN4A | |
| Trifluoroacetic Acid SCHEMBL19064739 | 0.83 | SCN9A (0.70) | SCN9ASCN7ASCN5ASCN1ASCN4A | |
| SCHEMBL21075310 | 0.83 | SCN9A (0.56) | SCN9ASCN7ASCN5ASCN1ASCN4A | |
| SCHEMBL21075609 | 0.82 | SCN9A (0.77) | SCN9ASCN7ASCN5ASCN1ASCN4A | |
| SCHEMBL21075259 | 0.82 | SCN9A (0.77) | SCN9ASCN7ASCN5ASCN1ASCN4A | |
| SCHEMBL17428649 | 0.81 | SCN9A (0.70) | SCN9ASCN7ASCN5ASCN1ASCN4A | |
| SCHEMBL21075735 | 0.80 | SCN9A (0.68) | SCN9ASCN7ASCN5ASCN1ASCN4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166939-B1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH INC (US) | 2019-06-05 | — | — | EP | disclosed |