Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GYS1 | P13807 | 9/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20307062 | 0.92 | SCN9A (0.47) | SCN9AALDH1A1GYS1L3MBTL1SCN5A | |
| SCHEMBL21075436 | 0.88 | SCN9A (0.48) | SCN9ASCN5A | |
| SCHEMBL21075447 | 0.88 | SCN9A (0.48) | SCN9ASCN5A | |
| SCHEMBL21075463 | 0.88 | SCN9A (0.48) | SCN9ASCN5A | |
| SCHEMBL17423149 | 0.85 | SCN9A (0.58) | SCN9ASCN5A | |
| SCHEMBL17428614 | 0.85 | SCN9A (0.58) | SCN9ASCN5A | |
| SCHEMBL21075537 | 0.83 | SCN9A (0.42) | SCN9AALDH1A1GYS1SCN5A | |
| SCHEMBL20697686 | 0.82 | SCN9A (0.45) | SCN9AALDH1A1GYS1L3MBTL1NPSR1 | |
| SCHEMBL17428308 | 0.82 | SCN9A (0.48) | SCN9AALDH1A1GYS1L3MBTL1SCN5A | |
| SCHEMBL21075350 | 0.81 | SCN9A (0.44) | SCN9AALDH1A1SCN5ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166939-B1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH INC (US) | 2019-06-05 | — | — | EP | disclosed |