Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 20/20 | 0.57 |
| ▸ | SCN5A | Q14524 | 11/20 | 0.55 |
| ▸ | SCN7A | Q01118 | 5/20 | 0.54 |
| ▸ | SCN2B | O60939 | 1/20 | 0.52 |
| ▸ | SCN1A | P35498 | 1/20 | 0.52 |
| ▸ | SCN4A | P35499 | 1/20 | 0.52 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.52 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.52 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21075307 | 1.00 | SCN9A (0.57) | SCN9ASCN5ASCN7ASCN2BSCN1A | |
| SCHEMBL19064897 | 0.96 | SCN9A (0.62) | SCN9ASCN5ASCN7ASCN2BSCN1A | |
| SCHEMBL17428408 | 0.96 | SCN9A (0.62) | SCN9ASCN5ASCN7ASCN2BSCN1A | |
| SCHEMBL17423139 | 0.96 | SCN9A (0.62) | SCN9ASCN5ASCN7ASCN2BSCN1A | |
| SCHEMBL21075386 | 0.92 | SCN9A (0.58) | SCN9ASCN5ASCN7ASCN2BSCN1A | |
| SCHEMBL21075601 | 0.90 | SCN9A (0.60) | SCN9ASCN5ASCN7ASCN2BSCN1A | |
| SCHEMBL19084108 | 0.89 | SCN9A (0.56) | SCN9ASCN5ASCN7ASCN2BSCN1A | |
| SCHEMBL21075635 | 0.88 | SCN9A (0.55) | SCN9ASCN5ASCN7ASCN2BSCN1A | |
| SCHEMBL17423111 | 0.88 | SCN9A (0.63) | SCN9ASCN5ASCN7ASCN2BSCN1A | |
| SCHEMBL17423158 | 0.88 | SCN9A (0.63) | SCN9ASCN5ASCN7ASCN2BSCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166939-B1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH INC (US) | 2019-06-05 | — | — | EP | disclosed |