Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 20/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.45 |
| ▸ | SCN7A | Q01118 | 3/20 | 0.45 |
| ▸ | SCN1A | P35498 | 3/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.44 |
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | SCN2B | O60939 | 1/20 | 0.43 |
| ▸ | SCN4A | P35499 | 1/20 | 0.43 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21075488 | 0.87 | SCN9A (0.49) | SCN9ASCN5ASCN7ASCN1ASCN2A | |
| SCHEMBL21075495 | 0.84 | SCN9A (0.47) | SCN9ASCN5ASCN7ASCN1ASCN2A | |
| SCHEMBL21075506 | 0.83 | SCN9A (0.67) | SCN9ASCN5ASCN7ASCN1ASCN2A | |
| SCHEMBL21075359 | 0.83 | SCN9A (0.54) | SCN9ASCN5ASCN7ASCN1ASCN2A | |
| SCHEMBL21075607 | 0.81 | SCN9A (0.67) | SCN9ASCN5ASCN7ASCN1ASCN2A | |
| SCHEMBL21075647 | 0.80 | SCN9A (0.61) | SCN9ASCN5ASCN7ASCN1ASCN2A | |
| SCHEMBL21075340 | 0.80 | SCN9A (0.69) | SCN9ASCN5ASCN7ASCN1ASCN2A | |
| SCHEMBL21075383 | 0.78 | SCN9A (0.72) | SCN9ASCN5ASCN7ASCN1ASCN2A | |
| SCHEMBL21075116 | 0.78 | SCN9A (0.68) | SCN9ASCN5ASCN7ASCN1ASCN2A | |
| SCHEMBL21075145 | 0.77 | SCN9A (0.55) | SCN9ASCN5ASCN7ASCN1ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166939-B1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH INC (US) | 2019-06-05 | — | — | EP | disclosed |