Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 13/20 | 0.48 |
| ▸ | SCN7A | Q01118 | 8/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 9/20 | 0.46 |
| ▸ | SCN1A | P35498 | 2/20 | 0.45 |
| ▸ | SCN4A | P35499 | 2/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.45 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.45 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | SCN2B | O60939 | 1/20 | 0.40 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19083867 | 1.00 | SCN9A (0.48) | SCN9ASCN7ASCN5ASCN1ASCN4A | |
| SCHEMBL21075695 | 0.94 | SCN9A (0.53) | SCN9ASCN7ASCN5ASCN1ASCN4A | |
| SCHEMBL19083845 | 0.94 | SCN9A (0.53) | SCN9ASCN7ASCN5ASCN1ASCN4A | |
| SCHEMBL17428512 | 0.91 | SCN9A (0.58) | SCN9ASCN7ASCN5ASCN1ASCN4A | |
| SCHEMBL16759197 | 0.87 | SCN7A (0.52) | SCN9ASCN7ASCN5ASCN1ASCN4A | |
| SCHEMBL16770783 | 0.87 | SCN7A (0.55) | SCN9ASCN7ASCN5ASCN1ASCN4A | |
| SCHEMBL17428596 | 0.86 | SCN9A (0.66) | SCN9ASCN7ASCN5ASCN1ASCN4A | |
| SCHEMBL19083942 | 0.83 | SCN9A (0.56) | SCN9ASCN7ASCN5ASCN1ASCN4A | |
| SCHEMBL19084035 | 0.83 | SCN9A (0.60) | SCN9ASCN7ASCN5ASCN1ASCN4A | |
| SCHEMBL16759454 | 0.81 | SCN9A (0.65) | SCN9ASCN7ASCN5ASCN1ASCN4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166939-B1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH INC (US) | 2019-06-05 | — | — | EP | disclosed |