Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 12/20 | 0.53 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.33 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.30 |
| ▸ | SCN1A | P35498 | 1/20 | 0.30 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17428770 | 0.89 | SCN9A (0.54) | SCN9ASCN5ASCN7AFFAR4SCN1A | |
| SCHEMBL19064870 | 0.89 | SCN9A (0.54) | SCN9ASCN5ASCN7AFFAR4SCN1A | |
| SCHEMBL15599056 | 0.84 | SCN9A (0.64) | SCN9ASCN5ASCN7ARXRANR1H2 | |
| SCHEMBL17423042 | 0.82 | SCN9A (0.56) | SCN9ASCN5ASCN7AFFAR4SCN1A | |
| SCHEMBL17423038 | 0.82 | SCN9A (0.56) | SCN9ASCN5ASCN7AFFAR4SCN1A | |
| SCHEMBL21075127 | 0.81 | SCN9A (0.56) | SCN9ASCN5ASCN7AFFAR4SCN1A | |
| SCHEMBL17428627 | 0.81 | SCN9A (0.67) | SCN9ASCN5ASCN7AFFAR4SCN1A | |
| SCHEMBL17428605 | 0.80 | SCN9A (0.60) | SCN9ASCN5ASCN7ASCN1ASCN2A | |
| SCHEMBL19064710 | 0.80 | SCN9A (0.60) | SCN9ASCN5ASCN7ASCN1ASCN2A | |
| SCHEMBL15543440 | 0.78 | SCN9A (0.68) | SCN9ASCN5ASCN7AFFAR4SCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166939-B1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH INC (US) | 2019-06-05 | — | — | EP | disclosed |