Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 18/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | SCN7A | Q01118 | 2/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.34 |
| ▸ | SCN2B | O60939 | 1/20 | 0.34 |
| ▸ | SCN1A | P35498 | 1/20 | 0.34 |
| ▸ | SCN4A | P35499 | 1/20 | 0.34 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21075631 | 0.90 | SCN9A (0.46) | SCN9ASCN7ASCN5ASCN2BSCN1A | |
| SCHEMBL21075516 | 0.90 | SCN9A (0.47) | SCN9AALDH1A1SCN7ASCN5A | |
| SCHEMBL17428496 | 0.90 | SCN9A (0.55) | SCN9ASCN7ASCN5ASCN2BSCN1A | |
| SCHEMBL17428493 | 0.82 | SCN9A (0.51) | SCN9ASCN7ASCN5ASCN2BSCN1A | |
| SCHEMBL17423354 | 0.80 | SCN9A (0.54) | SCN9ASCN7ASCN5ASCN2BSCN1A | |
| SCHEMBL17423353 | 0.80 | SCN9A (0.54) | SCN9ASCN7ASCN5ASCN2BSCN1A | |
| SCHEMBL17423253 | 0.80 | SCN9A (0.53) | SCN9ASCN5A | |
| SCHEMBL17423255 | 0.80 | SCN9A (0.53) | SCN9ASCN5A | |
| SCHEMBL21075324 | 0.79 | SCN9A (0.49) | SCN9ASCN7ASCN5ASCN2BSCN1A | |
| SCHEMBL19083968 | 0.79 | SCN9A (0.49) | SCN9ASCN7ASCN5ASCN2BSCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166939-B1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH INC (US) | 2019-06-05 | — | — | EP | disclosed |