Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 20/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.49 |
| ▸ | SCN1A | P35498 | 2/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.45 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21075334 | 0.90 | SCN9A (0.49) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL21075299 | 0.87 | SCN9A (0.46) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL21075323 | 0.87 | SCN9A (0.48) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL20697801 | 0.81 | SCN9A (0.47) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL21075515 | 0.80 | SCN9A (0.47) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL21075239 | 0.80 | SCN9A (0.66) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL20697639 | 0.79 | SCN9A (0.44) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL21075751 | 0.78 | SCN9A (0.47) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL17423017 | 0.78 | SCN9A (0.61) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL17428289 | 0.78 | SCN9A (0.61) | SCN9ASCN5ASCN1ASCN2ASCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166939-B1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH INC (US) | 2019-06-05 | — | — | EP | disclosed |