Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK3 | P27361 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.34 |
| ▸ | CASR | P41180 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | BCR | P11274 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | WNT1 | P04628 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21075927 | 0.97 | MAPK1 (0.66) | MAPK3MAPK1EIF2AK2CCNB2CDK1 | |
| SCHEMBL21075882 | 0.90 | MAPK1 (0.56) | MAPK3MAPK1EIF2AK2CCNB2CDK1 | |
| SCHEMBL21075925 | 0.90 | MAPK3 (0.56) | MAPK3MAPK1IKBKBCHUKIKBKG | |
| SCHEMBL21075891 | 0.90 | MAPK3 (0.56) | MAPK3MAPK1EIF2AK2CCNB2CDK1 | |
| SCHEMBL21075872 | 0.90 | MAPK3 (0.56) | MAPK3MAPK1EIF2AK2CCNB2CDK1 | |
| SCHEMBL21075977 | 0.89 | MAPK3 (0.55) | MAPK3MAPK1MAPK13MAPK12MAPK11 | |
| SCHEMBL21075890 | 0.87 | MAPK3 (0.52) | MAPK3MAPK1 | |
| SCHEMBL21075999 | 0.87 | MAPK3 (0.53) | MAPK3MAPK1 | |
| SCHEMBL21075929 | 0.87 | MAPK3 (0.53) | MAPK3MAPK1GSK3BWNT1DYRK1A | |
| SCHEMBL21075870 | 0.86 | MAPK3 (0.52) | MAPK3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3237423-B1 | THIENO[2,3-C]PYRROL-4-ONE DERIVATIVES AS ERK INHIBITORS | LILLY CO ELI (US) | 2019-06-05 | — | — | EP | disclosed |