Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1161193 | 0.83 | PDE1A (0.39) | PDE1APDE1BPDE1CKDM4EABCB1 | |
| SCHEMBL21017341 | 0.81 | PDE1A (0.40) | PDE1APDE1BPDE1CKDM4EABCB1 | |
| SCHEMBL19531886 | 0.80 | KDM5A (0.39) | PDE1APDE1BPDE1CKDM4EABCB1 | |
| SCHEMBL20676294 | 0.73 | PDE1B (0.40) | PDE1APDE1BPDE1CEIF4A3 | |
| SCHEMBL19531869 | 0.72 | CYP11B1 (0.48) | PDE1APDE1BPDE1CABCB1ABCG2 | |
| SCHEMBL20719675 | 0.71 | ABCB1 (0.33) | PDE1APDE1BPDE1CKDM4EABCB1 | |
| SCHEMBL20719723 | 0.71 | IRAK4 (0.36) | PDE1APDE1BPDE1CABCB1ABCG2 | |
| SCHEMBL19966537 | 0.69 | CDK4 (0.35) | PDE1APDE1BPDE1CABCB1ABCG2 | |
| SCHEMBL19698037 | 0.69 | PIK3CD (0.44) | PDE1APDE1BPDE1C | |
| SCHEMBL30632250 | 0.69 | EGFR (0.38) | PDE1APDE1BPDE1CABCB1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020151742-A1 | AMINO PYRIMIDINE COMPOUND FOR INHIBITING PROTEIN TYROSINE KINASE ACTIVITY | SHENZHEN TARGETRX, INC. (CN) | 2020-07-30 | — | — | WO | disclosed |
| EP-3492462-A1 | AMINO PYRIMIDINE COMPOUND FOR INHIBITING PROTEIN TYROSINE KINASE ACTIVITY | Shenzhen Targetrx, Inc. (CN) | 2019-06-05 | — | — | EP | disclosed |