Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.40 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.40 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20979106 | 0.89 | KDM4E (0.45) | KDM4EHRH3 | |
| SCHEMBL17888267 | 0.83 | CARM1 (0.60) | KDM4EGAASMN1; SMN2HRH3LMNA | |
| SCHEMBL17888266 | 0.83 | CARM1 (0.60) | KDM4EGAASMN1; SMN2HRH3LMNA | |
| SCHEMBL17277592 | 0.83 | CARM1 (0.60) | KDM4EGAASMN1; SMN2HRH3LMNA | |
| SCHEMBL21214401 | 0.80 | KDM4E (0.46) | KDM4EGAASMN1; SMN2HRH3LMNA | |
| SCHEMBL19226319 | 0.80 | KDM4E (0.46) | KDM4EGAASMN1; SMN2HRH3LMNA | |
| SCHEMBL20003977 | 0.80 | KDM4E (0.46) | KDM4EGAASMN1; SMN2HRH3LMNA | |
| SCHEMBL17886535 | 0.79 | HRH3 (0.42) | KDM4EGAASMN1; SMN2HRH3LMNA | |
| SCHEMBL17886875 | 0.79 | HRH3 (0.42) | KDM4EGAASMN1; SMN2HRH3LMNA | |
| SCHEMBL17886536 | 0.79 | HRH3 (0.42) | KDM4EGAASMN1; SMN2HRH3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |