Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 6/20 | 0.78 |
| ▸ | RET | P07949 | 12/20 | 0.63 |
| ▸ | KDR | P35968 | 8/20 | 0.63 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.63 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.63 |
| ▸ | LCK | P06239 | 3/20 | 0.63 |
| ▸ | SRC | P12931 | 3/20 | 0.63 |
| ▸ | CSK | P41240 | 3/20 | 0.63 |
| ▸ | BTK | Q06187 | 2/20 | 0.63 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.63 |
| ▸ | PLK4 | O00444 | 1/20 | 0.63 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.63 |
| ▸ | CASK | O14936 | 1/20 | 0.63 |
| ▸ | GAK | O14976 | 1/20 | 0.63 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.63 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.63 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.63 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.63 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.63 |
| ▸ | JAK2 | O60674 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12422383 | 0.93 | PIK3CD (0.73) | PIK3CDRETKDRPIK3CAPIK3CG | |
| SCHEMBL12022201 | 0.92 | PIK3CD (0.87) | PIK3CDRETKDRPIK3CAPIK3CG | |
| SCHEMBL12422337 | 0.91 | PIK3CD (0.84) | PIK3CDRETKDRPIK3CAPIK3CG | |
| SCHEMBL12422304 | 0.91 | PIK3CD (0.84) | PIK3CDRETKDRPIK3CAPIK3CG | |
| SCHEMBL1551638 | 0.90 | PIK3CD (0.75) | PIK3CDRETKDRPIK3CAPIK3CG | |
| SCHEMBL18922370 | 0.90 | PIK3CD (0.80) | PIK3CDRETKDRPIK3CAPIK3CG | |
| SCHEMBL12422336 | 0.90 | PIK3CD (0.82) | PIK3CDRETKDRPIK3CAPIK3CG | |
| SCHEMBL7944959 | 0.89 | PIK3CD (0.73) | PIK3CDRETKDRPIK3CAPIK3CG | |
| SCHEMBL12422377 | 0.89 | PIK3CD (0.68) | PIK3CDRETKDRPIK3CAPIK3CG | |
| SCHEMBL13826999 | 0.89 | PIK3CD (0.68) | PIK3CDRETKDRPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2976086-B1 | COMBINATION OF CATALYTIC MTORC 1/2 INHIBITORS AND SELECTIVE INHIBITORS OF AURORA A KINASE | MILLENNIUM PHARM INC (US) | 2020-10-14 | — | — | EP | disclosed |
| EP-3009436-B1 | KINASE INHIBITORS AND METHODS OF USE | INTELLIKINE LLC (US) | 2019-06-05 | — | — | EP | disclosed |